Endothelial to Mesenchymal Transition in Health and Disease

Xu, Yang and Kovacic, Jason C. (2023) Endothelial to Mesenchymal Transition in Health and Disease. Annual Review of Physiology, 85 (1). pp.245-267. ISSN 0066-4278

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The endothelium is one of the largest organ systems in the body, and data continue to emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and a range of cardiovascular diseases (CVDs). Over the last two decades and as a process intimately related to EC dysfunction, an increasing number of studies have also implicated endothelial to mesenchymal transition (EndMT) as a potentially disease-causal pathobiologic process that is involved in a multitude of differing CVDs. However, EndMT is also involved in physiologic processes (e.g., cardiac development), and transient EndMT may contribute to vascular regeneration in certain contexts. Given that EndMT involves a major alteration in the EC-specific molecular program, and that it potentially contributes to CVD pathobiology, the clinical translation opportunities are significant, but further molecular and translational research is needed to see these opportunities realized.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 06 Mar 2023 05:05
Last Modified: 09 Mar 2023 02:38
URI: http://eprints.victorchang.edu.au/id/eprint/1361

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