Donation After Circulatory Death: A New Frontier

Joshi, Yashutosh and Villanueva, Jeanette and Gao, Ling and Hwang, Bridget and Zhao, Christine and Doyle, Aoife and Wu, Jianxin and Jansz, Paul and Macdonald, Peter (2022) Donation After Circulatory Death: A New Frontier. Current Cardiology Reports, 24 (12). pp.1973-1981. ISSN 1523-3782

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PURPOSE OF REVIEW: To highlight the current global experience with DCD heart transplantation and explore the evolution of, and compare preservation strategies; examine early clinical outcomes, and discuss the growing use of DCD donors as a new frontier in heart transplantation. RECENT FINDINGS: The two strategies of DCD heart preservation include NMP using the OCS Heart and TA-NRP followed by either: NMP or CSS. Better understanding the limits of cold ischaemia following TA-NRP will aid in distant procurement. Asystolic warm ischaemia plays an important role in determining immediate post-operative graft function and potential need for mechanical support. Large volume DCD heart transplant units show no difference in survival between DCD and DBD donor heart transplants. In a previously non-utilised source of donor hearts, often viewed as an "unknown frontier" in heart transplantation, DCD hearts are a suitable alternative to brain-dead donor hearts and are likely to remain a permanent part of the heart transplantation landscape. Global uptake is currently increasing, and as understanding of preservation strategies and tolerable ischaemic times improve, utilisation of DCD hearts will continue to grow.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 03 Mar 2023 04:26
Last Modified: 20 Mar 2023 02:25

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