Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration

Hui, Subhra P. and Sugimoto, Kotaro and Sheng, Delicia Z. and Kikuchi, Kazu (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in Immunology, 13. ISSN 1664-3224

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Link to published document: http://doi.org/10.3389/fimmu.2022.981000

Abstract

The role of T cells in appendage regeneration remains unclear. In this study, we revealed an important role for regulatory T cells (Tregs), a subset of T cells that regulate tolerance and tissue repair, in the epimorphic regeneration of zebrafish caudal fin tissue. Upon amputation, fin tissue-resident Tregs infiltrate into the blastema, a population of progenitor cells that produce new fin tissues. Conditional genetic ablation of Tregs attenuates blastemal cell proliferation during fin regeneration. Blastema-infiltrating Tregs upregulate the expression of igf2a and igf2b, and pharmacological activation of IGF signaling restores blastemal proliferation in Treg-ablated zebrafish. These findings further extend our understandings of Treg function in tissue regeneration and repair.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 01 Mar 2023 01:10
Last Modified: 01 Mar 2023 01:10
URI: http://eprints.victorchang.edu.au/id/eprint/1285

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