Precision Medicine Approaches to Vascular Disease

Miller, Clint L. and Kontorovich, Amy R. and Hao, Ke and Ma, Lijiang and Iyegbe, Conrad and Björkegren, Johan L.M. and Kovacic, Jason C. (2021) Precision Medicine Approaches to Vascular Disease. Journal of the American College of Cardiology, 77 (20). pp.2531-2550. ISSN 07351097

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In this second of a 5-part Focus Seminar series, we focus on precision medicine in the context of vascular disease. The most common vascular disease worldwide is atherosclerosis, which is the primary cause of coronary artery disease, peripheral vascular disease, and a large proportion of strokes and other disorders. Atherosclerosis is a complex genetic disease that likely involves many hundreds to thousands of single nucleotide polymorphisms, each with a relatively modest effect for causing disease. Conversely, although less prevalent, there are many vascular disorders that typically involve only a single genetic change, but these changes can often have a profound effect that is sufficient to cause disease. These are termed "Mendelian vascular diseases," which include Marfan and Loeys-Dietz syndromes. Given the very different genetic basis of atherosclerosis versus Mendelian vascular diseases, this article was divided into 2 parts to cover the most promising precision medicine approaches for these disease types.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Repository Administrator
Date Deposited: 31 Jul 2021 05:19
Last Modified: 31 Jul 2021 05:19

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