Guo, Yang and Yu, Ze-Yan and Wu, Jianxin and Gong, Hutao and Kesteven, Scott and Iismaa, Siiri E and Chan, Andrea Y and Holman, Sara and Pinto, Silvia and Pironet, Andy and Cox, Charles D and Graham, Robert M and Vennekens, Rudi and Feneley, Michael P and Martinac, Boris (2021) The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy. eLife, 10. ISSN 2050-084X
Full text not available from this repository.Abstract
Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and remains the single most important clinical predictor of cardiac mortality. The molecular pathways in the induction of pressure overload LVH are potential targets for therapeutic intervention. Current treatments aim to remove the pressure overload stimulus for LVH, but do not completely reverse adverse cardiac remodelling. Although numerous molecular signalling steps in the induction of LVH have been identified, the initial step by which mechanical stretch associated with cardiac pressure overload is converted into a chemical signal that initiates hypertrophic signalling remains unresolved. In this study, we show that selective deletion of transient receptor potential melastatin 4 (TRPM4) channels in mouse cardiomyocytes results in an approximately 50% reduction in the LVH induced by transverse aortic constriction. Our results suggest that TRPM4 channel is an important component of the mechanosensory signalling pathway that induces LVH in response to pressure overload and represents a potential novel therapeutic target for the prevention of pathological LVH.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 31 Jul 2021 04:51 |
| Last Modified: | 31 Jul 2021 04:51 |
| URI: | http://eprints.victorchang.edu.au/id/eprint/1083 |
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