Moreno-Suarez, Ignacio and Scheer, Anna and Lam, Kaitlyn and Dembo, Lawrence and Spence, Angela L. and Hayward, Christopher and Kaye, David M. and Leet, Angela and Fuller, Louise M. and Jacques, Angela and Naylor, Louise H. and Green, Daniel J. and Maiorana, Andrew (2020) High-intensity interval training in patients with left ventricular assist devices: A pilot randomized controlled trial. The Journal of Heart and Lung Transplantation, 39 (12). pp.1380-1388. ISSN 10532498
Full text not available from this repository.Abstract
BACKGROUND: Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure. To date, studies evaluating the impact of aerobic training in patients with LVADs have focused on moderate-intensity exercise. METHODS: This pilot randomized controlled trial compared the effects of high-intensity interval training (HIIT) with those of moderate-intensity continuous training (MICT) on peak oxygen consumption (VO2 peak) in patients with LVADs. Secondary outcomes included 6-minute walk test distance, flow-mediated dilation, and anthropometry. Assessments were conducted at baseline and after 12 weeks of supervised training performed 3 times weekly. Participants were randomized to HIIT (4 sets of 4 minutes at 80%-90% VO2 reserve, alternating with 3 minutes at 50%-60% VO2 reserve) or MICT groups (28 minutes continuously at 50%-60% VO2 reserve). Within and between-group differences were analyzed using linear mixed models. Data are expressed as marginal means with 95% confidence intervals or as mean +/- SD. RESULTS: A total of 21 participants were randomized (HIIT: age 57.7 +/- 13.1 years; n=11 and MICT: age 55.6 +/- 14.2 years; n=10) (mean +/- SD). No major adverse events occurred in response to training in either group. HIIT significantly improved VO2 peak (15.6 [13.2-17.8] to 18.4 [16.0-20.8] ml/kg/min) (marginal mean [95% CI]) compared with MICT (16.2 [13.8-18.7] to 17.2 [14.6-19.7] ml/kg/min; p < 0.05 between groups). No significant group differences were detected in secondary outcomes. CONCLUSION: In patients with LVADs, HIIT was well tolerated and increased aerobic capacity more than MICT. These preliminary findings support the prescription of high-intensity exercise in clinically stable patients with LVADs but warrant validation in a larger sample and across a broader range of physiologic and clinical outcomes. CLINICAL TRIAL REGISTRATION: URL: https://www.anzctr.org.au, unique identifier: ACTRN12616001596493.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 16 Mar 2021 02:12 |
| Last Modified: | 16 Mar 2021 02:12 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1060 |
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