Madronio, Christine M. and Pathan, Shahab and Low, Gary K.K. and Nundlall, Nishant and Williams, Kathryn and Badorrek, Sally and Devadas, Michael and Gallaty, Lynette and Madan, Kedar and Loh, Han and Ahmad, Shiva and Negishi, Kazuaki and Pathan, Faraz (2025) The Effect of Body Size and Obesity on Cardiovascular Haemodynamics and Myocardial Mechanics. Heart, Lung and Circulation, 34 (10). pp.1109-1118. ISSN 14439506
Full text not available from this repository.Abstract
BACKGROUND: To improve management of cardiovascular-kidney-metabolic syndrome, a better understanding of the early effects of body size on the heart is crucial and remains under investigation, considering the increasing global prevalence of obesity. Most data available on cardiovascular haemodynamics come from echocardiography despite the known challenges in image acquisition in the context of overweight and obesity. Using cardiac magnetic resonance imaging, we aimed to further investigate the effect of body size on cardiac output (CO) and other early imaging biomarkers of cardiovascular disease. METHOD: Participants including healthy volunteers and individuals with obesity who were planning to undergo bariatric surgery were recruited from two completed studies. The participants underwent cardiac magnetic resonance imaging. Measures of cardiovascular haemodynamics and myocardial mechanics were collected, including CO, stroke volume, heart rate, chamber volumes, and myocardial strain. The relationship of these variables with body size were assessed. RESULTS: A total of 57 participants were recruited (79% female; mean age, 41 years). A positive linear relationship was observed between CO vs body mass index (BMI) (p<0.01) and body surface area (BSA) (p<0.01). A similar trend was seen with stroke volume vs BSA (p<0.01) and BMI (p<0.01). Indexation to BSA rendered chamber volumes similar. We found significant differences in left and right atrial strain between the groups. Regression analysis demonstrated an association between left ventricular global longitudinal strain and right atrial strain with BSA and between left ventricular global longitudinal strain, right ventricular free wall strain, and right atrial strain with BMI. CONCLUSIONS: Obesity is associated with increased CO; this increase is a result of cardiac remodelling and consequent increase in stroke volume. Obesity is associated with an impairment of subclinical markers of cardiovascular disease measured using multichamber strain.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 21 Dec 2025 23:28 |
| Last Modified: | 21 Dec 2025 23:28 |
| URI: | http://eprints.victorchang.edu.au/id/eprint/1789 |
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