Deshmukh, Tejas and Hume, Robert D. and Chen, Siqi and Igoor, Sindhu and Foster, Sheryl L. and Barry, Tony and Lu, Juntang and Tran, Vu and Pouliopoulos, Jim and Jabbour, Andrew and Vigder, Niv and Cordwell, Stuart J. and Tumanov, Sergey and Nguyen, Christopher and Kotake, Yasuhito and Turnbull, Samual and Campbell, Tim and Pathan, Faraz and Kumar, Saurabh and Kizana, Eddy and Chong, James J. H. (2025) Platelet derived growth factor-AB modulates post-infarct myocardium leading to extended improvement in cardiac function. npj Regenerative Medicine, 10 (1). ISSN 2057-3995
Full text not available from this repository.Abstract
Myocardial infarction (MI) contributes to significant morbidity and mortality globally. Platelet derived growth factor-AB (PDGF-AB) is potentially a novel translational therapeutic for improving cardiac function post-MI, which we assess here using a 60 day porcine left anterior descending artery occlusion ischemia-reperfusion model. MI was induced in 10 female Landrace swine, with 5 controls, 5 receiving PDGF-AB treatment and 2 additional shams. PDGF-AB improved left ventricular ejection fraction 58 days after MI, without affecting overall infarct scar size, as shown using serial cardiac magnetic resonance imaging. Preserved infarct zone microvascular function and increased vessel maturity was also observed. Multi-omic analyses showed that PDGF-AB treatment altered the expression of proteins, metabolites, and lipids that are known to be involved in myocardial energetics and redox balance. Novel therapeutics such as PDGF-AB may lead to more sustained salvage of cardiac function by modulating the post-MI microvasculature, myocardium and extracellular matrix.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 20 Dec 2025 04:31 |
| Last Modified: | 20 Dec 2025 04:31 |
| URI: | http://eprints.victorchang.edu.au/id/eprint/1782 |
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