Banks, Alexander S. and Allison, David B. and Alquier, Thierry and Ansarullah, . and Austad, Steven N. and Auwerx, Johan and Ayala, Julio E. and Baur, Joseph A. and Carobbio, Stefania and Churchill, Gary A. and Dall, Morten and de Cabo, Rafael and Donato, Jose and Dragano, Nathalia R. V. and Elias, Carol F. and Ferrante, Anthony W. and Finck, Brian N. and Galgani, Jose E. and Gerhart-Hines, Zachary and Goodyear, Laurie J. and Grobe, Justin L. and Gupta, Rana K. and Habegger, Kirk M. and Hartig, Sean M. and Hevener, Andrea L. and Heymsfield, Steven B. and Holman, Corey D. and de Angelis, Martin Hrabě and James, David E. and Kazak, Lawrence and Kim, Jae Bum and Klingenspor, Martin and Kong, Xingxing and Kooijman, Sander and Lantier, Louise and Lloyd, K. C. Kent and Lo, James C. and Lodhi, Irfan J. and MacLean, Paul S. and McGuinness, Owen P. and Medina-Gómez, Gema and Mirmira, Raghavendra G. and Morrison, Christopher D. and Morton, Gregory J. and Müller, Timo D. and Ogawa, Yoshihiro and Pajuelo-Reguera, David and Potthoff, Matthew J. and Qi, Nathan and Reitman, Marc L. and Rensen, Patrick C. N. and Rozman, Jan and Rutkowsky, Jennifer M. and Sakamoto, Kei and Scherer, Philipp E. and Schwartz, Gary J. and Sedlacek, Radislav and Selloum, Mohammed and Shaikh, Saame Raza and Chen, Shuai and Shulman, Gerald I. and Škop, Vojtěch and Soukas, Alexander A. and Speakman, John R. and Spiegelman, Bruce M. and Steinberg, Gregory R. and Svensson, Katrin J. and Thyfault, John P. and Tiganis, Tony and Titchenell, Paul M. and Turner, Nigel and Velloso, Licio A. and Vidal-Puig, Antonio and Ward, Christopher S. and Williams, Ashley S. and Wolfrum, Christian and Xu, Allison W. and Xu, Ying and Zierath, Juleen R. (2025) A consensus guide to preclinical indirect calorimetry experiments. Nature Metabolism, 7 (9). pp.1765-1780. ISSN 2522-5812
Full text not available from this repository.Abstract
Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure. Using measurements of respiratory gas exchange, indirect calorimetry can provide non-invasive estimates of whole-body energy expenditure. However, inconsistent measurement units and flawed data normalization methods have slowed progress in this field. This guide aims to establish consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results. By establishing community-driven standards, we hope to facilitate data comparison across research datasets. This advance will allow the creation of an in-depth, machine-readable data repository built on shared standards. This overdue initiative stands to markedly improve the accuracy and depth of efforts to interrogate mammalian metabolism. Data sharing according to established best practices will also accelerate the translation of basic findings into clinical applications for metabolic diseases afflicting global populations.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 20 Dec 2025 04:01 |
| Last Modified: | 20 Dec 2025 04:01 |
| URI: | http://eprints.victorchang.edu.au/id/eprint/1773 |
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