Davidson, Nicholas and Lee, Felicity and Lambert, James and Laycock, Andrew and Allanson, Benjamin and Dwivedi, Girish (2025) Cardiac Granulomatous Disease Following Silicone Breast Augmentation. JACC: Case Reports, 30 (21). p. 104357. ISSN 26660849
Full text not available from this repository.Abstract
Cardiac sarcoidosis is a rare cause of symptomatic sinoatrial node dysfunction (SND). Silicone breast augmentation has been associated with various phenotypes of sarcoidosis, but not to our knowledge with cardiac involvement. We present a case of a 50-year-old woman who presented with symptomatic SND and was found to have silicone breast implant rupture, disseminated thoracic lymphadenopathy, and extensive cardiac infiltration. Lymph node biopsy demonstrated non-necrotizing granuloma and refractile nonbirefringent material consistent with sarcoidosis or disseminated silicone granulomatosis. The patient did not respond to implant removal alone, but demonstrated a significant response to high-dose glucocorticoids and adjuvant immunosuppression (methotrexate and adalimumab). We hypothesize that silicone from the ruptured implants served as an immunologic adjuvant triggering an autoimmune/inflammatory syndrome induced by adjuvants-type reaction indistinguishable from sarcoidosis, of which this is the first described involving the heart.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 03 Nov 2025 02:30 |
| Last Modified: | 03 Nov 2025 02:30 |
| URI: | http://eprints.victorchang.edu.au/id/eprint/1738 |
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