Lee, Angela W C and Sillett, Charles and Solis-Lemus, José Alonso and Kessler Iglesias, Cassia and Hopman, Luuk H G A and Hua, Alina and Wheen, Peter and Qayyum, Abdul and Strocchi, Marina and Roney, Caroline and Booth, Thomas and Ismail, Tevfik F and Chubb, Henry and Ennis, Daniel B and Jabbour, Andrew and Fatkin, Diane and Götte, Marco J W and Niederer, Steven A (2025) Is regional atrial strain a useful surrogate of regional atrial fibrosis in atrial cardiomyopathy? European Heart Journal - Imaging Methods and Practice, 3 (2). ISSN 2755-9637
Full text not available from this repository.Abstract
Abstract Aims
To determine whether atrial biomechanics measured using 3D regional strain, left atrial volume (LAV), and left atrial emptying fraction (LAEF) are associated with atrial fibrosis in patients with suspected atrial cardiomyopathy.
Methods and results
Cardiovascular magnetic resonance (CMR) was performed in atrial fibrillation (AF) patients (n = 47). Healthy volunteer (n = 41) and familial dilated cardiomyopathy (DCM) (n = 31) cohorts were acquired for normalization and validation, respectively. Fibrosis was quantified using late gadolinium enhancement (LGE)-CMR, and 3D regional strain was quantified using feature tracking. Machine learning classifiers were used to classify regional severe fibrosis (>30% LGE enhancement) using regional strain and global measures of atrial anatomy and function. 3D regional strain measures (peak reservoir strain or first/second strain principal component) alone were not associated with regional fibrosis (accuracies ≤ 56.0%) in the AF cohort. Severe fibrosis was found primarily in the lateral (85.1% of AF patients) and posterior (66.0%) regions. In AF patients, the classifier incorporating LAV, LAEF, and regional location was associated with severe regional fibrosis (AUC = 0.86 ± 0.06, accuracy = 79.4 ± 6.2%), while in familial DCM patients, the accuracy was lower (62.8%).
Conclusion
There is a distinctive pattern of fibrosis that develops with progression of atrial cardiomyopathy, irrespective of cause. Global measures reflecting overall atrial anatomy (LAV) and function (LAEF), rather than localized regional 3D strain, were associated with severe regional fibrosis. These data suggest that regional atrial 3D strain alone is not a reliable surrogate for severe regional fibrosis.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 31 Oct 2025 04:41 |
| Last Modified: | 31 Oct 2025 04:41 |
| URI: | http://eprints.victorchang.edu.au/id/eprint/1714 |
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