Balaji, Poornima and Liulu, Xingzhou and Sivakumar, Sonaali and Chong, James J.H. and Kizana, Eddy and Vandenberg, Jamie I. and Hill, Adam P. and Hau, Eric and Qian, Pierre C. (2025) Mechanistic Insights and Knowledge Gaps in the Effects of Radiation Therapy on Cardiac Arrhythmias. International Journal of Radiation Oncology*Biology*Physics, 121 (1). pp.75-89. ISSN 03603016
Full text not available from this repository.Abstract
Stereotactic body radiation therapy (SBRT) is an innovative modality for the treatment of refractory ventricular arrhythmias (VAs). Phase 1/2 clinical trials have demonstrated the remarkable efficacy of SBRT at reducing VA burden (by >85%) in patients with good short-term safety. SBRT as an option for VA treatment delivered in an ambulatory nonsedated patient in a single fraction during an outpatient session of 15 to 30 minutes, without added risks of anesthetic or surgery, is clinically relevant. However, the underlying mechanism remains unclear. Currently, the clinical dosing of SBRT has been derived from preclinical studies aimed at inducing transmural fibrosis in the atria. The propitious clinical effects of SBRT appear earlier than the time course for fibrosis. This review addresses the plausible mechanisms by which radiation alters the electrophysiological properties of myocytes and myocardial conduction to impart an antiarrhythmic effect, elucidate clinical observations, and point the direction for further research in this promising area.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Repository Administrator |
| Date Deposited: | 05 May 2025 00:35 |
| Last Modified: | 05 May 2025 00:35 |
| URI: | https://eprints.victorchang.edu.au/id/eprint/1651 |
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